Extreme overdosage may possibly bring about coma, areflexia, cardiorespiratory depression and apnea. The consequences of overdosage is usually managed with benzodiazepine antagonist flumazenil.
In Glossip v. Gross, attorneys for 3 Oklahoma inmates argued that midazolam couldn't achieve the extent of unconsciousness demanded for surgery, this means intense agony and struggling was probable. They argued that midazolam was cruel and weird punishment and therefore Opposite to your Eighth Amendment to America Constitution.
Explain to your doctor For anyone who is breastfeeding. Never breastfeed within four to 8 several hours just after acquiring midazolam. If you're breastfeeding, notify your health care provider for those who detect extreme sedation, bad feeding, and bad weight achieve during the nursing little one.
Usually speak to your healthcare service provider to be sure the knowledge shown on this web page relates to your own conditions.
Ensure you know the way to take midazolam and what other medicine you ought to prevent using with it. See also Drug Interactions portion. Get healthcare help right away if any of these very critical Unintended effects happen: slow/shallow respiratory, abnormal lightheadedness, extreme drowsiness/dizziness, issues waking up.
Midazolam maleate (a by-product of Midazolam) is described as an component of Dormicum in the following nations:
In 2011, the European Medicines Agency (EMA) granted a marketing authorisation for any buccal software kind of midazolam, marketed beneath the brand name name Buccolam. Buccolam was to begin with authorized with the cure of prolonged, acute, convulsive seizures in people today from three months to under eighteen several years of age.
If you employ midazolam throughout pregnancy, your toddler could possibly be born with existence-threatening withdrawal symptoms, and might require health care therapy for many weeks.
Get health-related assistance immediately if you have any extremely critical side effects, which include: fainting, swift/slow/shallow respiratory.
Midazolam can slow or stop your breathing, especially if you've not too long ago employed an opioid medication or Liquor. An individual caring for you need to find emergency health-related consideration Should you have sluggish respiration with prolonged pauses, blue read more colored lips, or For anyone who is difficult to get up.
Midazolam ought to not be presented to individuals with severe respiratory insufficiency, critical hepatic insufficiency, myasthenia gravis, rest apnea syndrome and with known hypersensitivity to benzodiazepines or to any part from the product
[82] Midazolam functions as a sedative but will fail to render the condemned prisoner unconscious, at which period vecuronium bromide and potassium chloride are administered, halting the prisoner's respiratory and coronary heart, respectively. Since the condemned prisoner is not rendered unconscious but is just sedated, the administration of vecuronium bromide and potassium chloride may cause Excessive agony and worry in the individual being executed.[83]
Disadvantages include things like a higher degree of breakthrough seizures—a result of the shorter 50 %-lifetime of midazolam—in over fifty% of folks addressed, in addition to treatment method failure in fourteen–eighteen% of those with refractory standing epilepticus. Tolerance develops promptly to the anticonvulsant impact, plus the dose may perhaps should be increased by several occasions to maintain anticonvulsant therapeutic consequences.
Midazolam is injected right into a muscle mass or into a vein. A Health care provider provides you with this injection.